Driving out of Heraklion airport you come to a cross road.  Drive straight ahead and take the first turn off point to the right (+/-500m).  This will take you directly onto the national road towards Rethymno (head west).  Keep on driving for about an hour without turning off and when you come to the area of Skaleta you on the right hand side you will come to a turn-off point with a large sign "old national road" which takes you down onto the old road.  Turn left.  Once you are on this road after about 2 km Aquila Rithymna Beach hotel is on the right hand side.